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August 22, 2022 Cover

Volume 100, Issue 29

Researchers have already hijacked the body’s protein-disposal system with bifunctional protein degraders, or PROTACs. Small-molecule glues can do more with less—but can we find them?

Cover image:Researchers have already hijacked the body’s protein-disposal system with bifunctional protein degraders, or PROTACs. Small-molecule glues can do more with less—but can we find them?

Credit: Will Ludwig/C&EN/Novartis/Mark Mazaitis

Full Article

Molecular glues are beginning to stick

Researchers have already hijacked the body’s protein-disposal system with bifunctional protein degraders, or PROTACs. Small-molecule glues can do more with less—but can we find them?

  • Simple method creates stretchy, color-changing films

    The easy-to-make materials could find use in medicine and robotics

  • What’s in the Inflation Reduction Act for chemistry?

    Law supports carbon capture, green power, and low-emission transportation with billions of federal dollars

  • PFAS testing needed for those with high exposure

    US National Academies says people with elevated PFAS levels should be monitored for adverse health outcomes

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